APPENDIX II-BW: Piperonyl Butoxide: Hydrolysis Half-Life 250 Days; Aerobic Soil Half-Life 79 days; Anaerobic Soil Half-Life 927 Days.

This appendix copied from:

http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33240

Piperonyl butoxide - Identification, toxicity, use, water pollution potential, ecological toxicity and regulatory information

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Chemical ID

Identifying information, including synonyms, ID numbers, use type, chemical classification, a link to a list of all products containing this chemical and a list of the top crops this pesticide is used on in California.

Poisoning Symptoms

Signs and symptoms of poisoning, first aid, and links to treatment information for this chemical.

Toxicity

Toxicity to humans, including carcinogenicity, reproductive and developmental toxicity, neurotoxicity, and acute toxicity.

Regulatory

Links to world-wide registration status as well as regulatory information for the U.S. and California.

Water

Water quality standards and physical properties affecting water contamination potential.

Ecotoxicity

Toxicity to aquatic organisms.

Related Chems

List of chemicals in the same family, including breakdown products, salts, esters, isomers, and other derivatives.

Chemical Identification and Use for Piperonyl butoxide

Basic Identification Information About This Chemical
Chemical Name:	Piperonyl butoxide
CAS Number:	51-03-6
U.S. EPA PC Code:	067501
CA DPR Chem Code:	486
Molecular Weight:	388.4500
Molecular Structure:
Use Type:	Synergist
Chem Class:	Unclassified
View Related Chemicals
Additional Resources About This Chemical Class and Use Type
See the Global Pesticide Resources page for many additional links.
Historical Use of this Chemical Top five crops and sites for this pesticide in California
Public Health Pest Control Structural Pest Control Tomatoes Lemons Landscape View All Crops and Sites
Other Names for this Chemical About Chemical Synonyms
(Butylcarbityl)(6-propylpiperonyl) ether 80% and related compounds 20% , 00486 (CA DPR Chem Code) , 067501 (US EPA PC Code) , 1,3-Benzodioxole, 5-((2-(2-butoxyethoxy)ethoxy)methyl)-6-propyl- , 486 (CA DPR Chem Code) , 5-((2-(2-Butoxyethoxy)ethoxy)methyl)-6-propyl-1,3-benzodioxole , 51-03-6 (CAS Number) , 51036 , 51036 (CAS Number) , 6-Propylpiperonyl butyl diethyleneglycol ether , alpha-(2-(2-Butoxyethoxy)ethoxy)-4,5-(methylenedioxy)-2-propyltoluene , Butacide , Butyl carbitol 6-propylpiperonyl ether , But—xido de piperonilo , ENT-14250 , PBO , Piperony butoxide , piperonyl , Piperonyl butoxide , piperonyl butoxyde , piperonylbutoksid , Piperonylbutoxid (Synergist) , Piperonylbutoxide , Piperonylbutoxyd , Pybuthrin
Products Containing This Chemical Current and historic U.S. registered products
View U.S. Products All Products (7395 Total) Currently Registered Products (1517 Total)

Signs and Symptoms of Piperonyl butoxide Poisoning

	NOTE! There may be other diseases and chemicals that have similar symptoms.
	If you have a poisoning emergency in the United States call 1-800-222-1222. If the victim has collapsed or is unconscious, call 911.

Symptoms of Piperonyl butoxide Exposure from the International Chemical Safety Cards (ICSC)		Report a Poisoning
View full ICSC Cards: English Español Française Chinese Dutch Finnish German Hungarian Japanese Swahili Thai Urdu
NOTE! PREVENT GENERATION OF MISTS!
Route of Exposure	Symptoms	First Aid
Inhalation		Fresh air rest.
Skin		Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes		First rinse with plenty of water for several minutes (remove contact lenses if easily possible) then take to a doctor.
Ingestion	Diarrhoea. Vomiting.	Rinse mouth. Give plenty of water to drink. Rest. Refer for medical attention.
Notes for ICSC Information

Toxicity Information for Piperonyl butoxide

Note: Information for many chemicals is incomplete and may not be fully representative of effects on humans. Why?

Summary Toxicity Information
PAN Bad Actor Chemical^1	Acute Toxicity^2	Carcinogen	Cholinesterase Inhibitor	Ground Water Contaminant	Developmental or Reproductive Toxin	Endocrine Disruptor
Not Listed	Moderate	Possible	No	Potential

	Indicates high toxicity in the given toxicological category.		Indicates no available weight-of-the-evidence summary assessment. For additional information on toxicity from scientific journals or registration documents, see the "Additional Resources for Toxicity " section of the chemical detail page.
1. PAN Bad Actors are chemicals that are one or more of the following: highly acutely toxic, cholinesterase inhibitor, known/probable carcinogen, known groundwater pollutant or known reproductive or developmental toxicant. NOTE! Because there are no authoritative lists of Endocrine Disrupting (ED) chemicals, EDs are not yet considered PAN Bad Actor chemicals.
2. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above.

Additional Resources about the Toxicity of this Chemical

Additional Toxicity Info for this Chemical - ChemFinder Datasheet on Piperonyl butoxide - PubMed search using CAS Number for Piperonyl butoxide - PubMed search for Piperonyl butoxide Detailed Cancer Assessment for Piperonyl butoxide, INCHEM IARC, Volume 30, 1983 Emergency procedures (spills, fire, poisoning) for Piperonyl Butoxide, INCHEM ICSC 1965 Toxicity Assessment of Piperonyl Butoxide Residues in Food, INCHEM JMPR 1966 Toxicity Assessment of Piperonyl butoxide Residues in Food, INCHEM JMPR 1967 Toxicity Assessment of Piperonyl butoxide Residues in Food, INCHEM JMPR 1969 Toxicity Assessment of Piperonyl Butoxide Residues in Food, INCHEM JMPR 1972 Toxicity Assessment of Piperonyl butoxide Residues in Food, INCHEM JMPR 1992 Toxicity Assessment of Piperonyl butoxide Residues in Food, INCHEM JMPR 1995 Toxicity Assessment of Piperonyl butoxide Residues in Food, INCHEM JMPR

See the Global Pesticide Resources page for many additional links.

Detailed Toxicity Information
Acute Toxicity ^2
WHO Acute Hazard TRI Acute Hazard Material Safety Data Sheets Acute rating from U.S. EPA product label U.S. NTP Acute Toxicity Studies View Studies Cholinesterase Inhibitor	U, Unlikely to be Hazardous Not Listed Not Available Slightly Toxic Not Acutely Toxic to Moderately Toxic No
2. The acute toxicity reported on this page is of the pure chemical ingredient only and may not reflect the acute toxicity of individual pesticide products. To view acute toxicity of individual products, click on 'View Products' link in the 'Chemical Identification' section above.
Cancer Information
IARC Carcinogens U.S. NTP Carcinogens California Prop 65 Known Carcinogens U.S. EPA Carcinogens TRI Carcinogen	3, Unclassifiable Not Listed Not Listed C, Possible Not Listed
Endocrine Disruption
Illinois EPA list Keith list Colborn list Benbrook list EU list	Not listed Not listed Not listed Not listed
Reproductive and Developmental Toxicity
CA Prop 65 Developmental Toxin U.S. TRI Developmental Toxin CA Prop 65 Female Reproductive Toxin CA Prop 65 Male Reproductive Toxin U.S. TRI Reproductive Toxin	Not Listed Not Listed Not Listed Not Listed Not Listed
Chemicals of Special Concern
PAN Bad Actors PAN Dirty Dozen list	Not Listed Not Listed

Water Pollution Potential and Criteria for Piperonyl butoxide

Water Pollution Potential
PAN Ground Water Contaminant Rating	Potential
Physical Property Data Related to Water Contamination Potential
Water Solubility (Avg, mg/L) Adsorption Coefficient (Koc) Hydrolysis Half-life (Avg, Days) Aerobic Soil Half-life (Avg, Days) Anaerobic Soil Half-life (Avg, Days)	14.0 1,805 250.0 79.0 927.0
Sorry, no water quality standards or criteria have been established for this chemical by the U.S. or Canadian governments; however, there may be criteria established for related chemicals.

Regulatory Information for Piperonyl butoxide

International Regulatory Status
Worldwide Registration Click on link at right to view registration information for different countries -->	Worldwide Registration for: Piperonyl butoxide Number of countries where this chemical is:      Banned, Restricted or Cancelled: 0      Not legal for import: 0
UNEP Persistent Organic Pollutant (POP) UNEP Prior Informed Consent Chemical (PIC) WHO Obsolete Pesticide	Not Listed Not Listed Not Listed
U.S. and California Regulatory Status
U.S. EPA Registered U.S. EPA Hazardous Air Pollutant U.S. EPA Minimum Risk Pesticide (25b list) CA Registered CA Groundwater Contaminant CA Toxic Air Contaminant	Yes Not Listed No Yes Not Listed Candidate
Maximum Tolerance and Residue Levels
Codex Alimentarius    (UN FAO Maximum Residue Limits) U.S. Maximum Tolerance Levels European Union Maximum Residue Levels	Go to web site Go to web site Go to web site

Ecotoxicity for Piperonyl butoxide

Note! Information for many chemicals is incomplete and may not be fully representative of effects on the environment. Why? Click on underlined terms for definitions and additional information.

Aquatic Ecotoxicity

All Toxic Effects for Organism Group
Organism Group	Effects Noted
Amphibians	Mortality
Annelida	Mortality
Crustaceans	Accumulation, Mortality
Fish	Biochemistry, Enzyme(s), Genetics, Mortality
Insects	Intoxication, Mortality
Molluscs	Intoxication, Physiology
Zooplankton	Intoxication, Mortality
View All Aquatic Ecotoxicity Studies and References

Summary of Acute Toxicity for Organism Group
Organism Group	Average Acute Toxicity	Acute Toxicity Range
Amphibians	Highly Toxic	Moderate to High Toxicity
Annelida	Moderately Toxic	Moderate Toxicity
Crustaceans	Moderately Toxic	Moderate to Very High Toxicity
Fish	Moderately Toxic	Moderate Toxicity
Insects	Moderately Toxic	Moderate Toxicity
Zooplankton	Moderately Toxic	Moderate to High Toxicity
View All Acute Summaries

Terrestrial Ecotoxicity

We are seeking funding to incorporate terrestrial ecotoxicity data analogous to the aquatic ecotoxicity data in the space above. Watch this space!

Related Chemicals for Piperonyl butoxide

CAS Number	Relation	Reason	Chemical Name	Chem Detail	Registration	Symptoms	California Use	Chem Use Type	U.S. EPA Reg	PAN Bad Actor
51-03-6	Parent	P	Piperonyl butoxide	View	View	View	View	Synergist	Yes	Not Listed
	Related	8	Piperonyl butoxide, technical, other related	View	View	View	View	Synergist	Yes	Not Listed

Working with the Information on this Page

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* Data marked with an asterisk indicates that this chemical is not explicitly listed on the corresponding list. Instead, it belongs to a group of chemicals that IS designated on the list. For example, if an agency assigns a classification of reproductive toxicant to "mercury compounds", that classification is applied to all mercury compounds in the PAN Pesticide database, which are then marked with an asterisk.

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Citation: S. Kegley, B. Hill, S. Orme, PAN Pesticide Database, Pesticide Action Network, North America (San Francisco, CA. 2007), http:www.pesticideinfo.org.
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